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KMID : 1149220130210020044
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Korean Journal of Oriental Medical Prescription
2013 Volume.21 No. 2 p.44 ~ p.52
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Chun Jin-Mi
Choi Go-Ya
Kim Dong-Seon
Sung Yoon-Young
Nho Kyoung-Jin
Kim Seung-Hyung
Kim Ho-Kyoung
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Abstract
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Objectives : Samhwangsasim-tang (SST), Hwangryeonhaedok-tang (HHT), Ukgan-san (UGS), Onjunghwadam-hwan (OHH) and Samul-tang (SMT) have been used for the treatment of various diseases. This study was performed to compare the anti-obesity effects of 5 herbal formulas in high fat diet-(HFD) induced obese mice.
Methods : The mice were randomly divided into seven groups that were fed a normal diet (ND), a HFD, a HFD plus SST (HFD + SST), a HFD plus HHT (HFD + HHT), a HFD plus UGS (HFD + UGS), a HFD plus OHH (HFD + OHH), or HFD plus SMT (HFD + SMT) at 300 mg/kg/day for 7 weeks. All groups were assayed for body weights, food efficiency ratio (FER), final liver and fat weight and blood biochemical parameters.
Results : The increased body weights, food efficiency ratio (FER), and serum total triglyceride were decreased in HFD + OHH group relative to the same measurements in HFD group. Furthermore, the HFD + SST group significantly reduced FER, liver and abdominal subcutaneous fat weight gains, and serum total triglyceride, whereas HDL-cholesterol level was increased compared to HFD group.
Conclusions : These results suggested that HFD + OHH and HFD + SST exert anti-obesity effects in HFDinduced obese mice.
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KEYWORD
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5 herbal formulas, Anti-obesity effects, High-fat diet-induced obese mice, Onjunghwadam-hwan, Samhwangsasim-tang
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